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The loss dropped Chicago to an MLB-worst 17-51.
Logan Gilbert struck out eight and allowed three runs and six hits over 6 2/3 innings.
George Kirby completed seven innings, allowing a run on five hits with four strikeouts.
Bryan Woo (3-0) remained unbeaten after pitching out of a pair of early jams.
The ban will continue until further notice.
Leaving Oakland after this season, the A’s drew an announced crowd of 9,735 at the Coliseum.
Before the game, the Mariners announced the signing of free agent outfielder Victor Robles.
Marcano was the first active major leaguer banned for life under the sport’s gambling provision since New York Giants outfielder Jimmy O’Connell in 1924.
Luis Castillo was brilliant in his first win since May 12.
The storm system could cause some ponding on streets and highways, so drivers are warned to drive cautiously next week.