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AL West champion Seattle had some extra time off, but the status of All-Star right-hander Bryan Woo (15-7, 2.94 ERA) was still uncertain.
The Mariners will take on the winner of the first-round series between the Detroit Tigers and Cleveland Guardians in the AL Division Series starting Saturday.
RHP George Kirby (10-7, 4.24) starts Friday’s series opener against the visiting Los Angeles Dodgers, who send RHP Emmet Sheehan (6-3, 2.86) to the mound,
The Cardinals trailed 20-6 midway through the fourth.
The streaking Mariners clinched the fourth division crown in the franchise’s 49-year history.
Rockies RHP Tanner Gordon (6-7, 6.00 ERA) starts Wednesday against Mariners RHP Luis Castillo (10-8, 3.63).
The Astros never led in the series and went 2 for 20 with runners in scoring position.
The Seahawks visit Arizona on Thursday.
The Mariners begin their pivotal series in Houston with RHP Bryan Woo (14-7, 3.02 ERA) on the mound Friday night.
The teams complete their three-game series on Thursday.