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The Astros never led in the series and went 2 for 20 with runners in scoring position.
The Seahawks visit Arizona on Thursday.
The Mariners begin their pivotal series in Houston with RHP Bryan Woo (14-7, 3.02 ERA) on the mound Friday night.
The teams complete their three-game series on Thursday.
The Storm will play at Las Vegas on Thursday for a spot in the WNBA semifinals.
Mariners RHP Bryce Miller (4-5, 5.59 ERA) gets the start Wednesday night after striking out a career-high 11 in his last start against the Angels.
Mariners: RHP Logan Gilbert (4-6, 3.54) starts Tuesday at Kansas City, which goes with RHP Michael Wacha (9-11, 3.45).
The Seahawks host New Orleans next Sunday.
Angels LHP Yusei Kikuchi (6-11, 4.18 ERA) faces Mariners RHP Luis Castillo (9-8, 3.85) on Friday night.
Mariners RHP Bryce Miller (4-5, 5.53 ERA) faces Angels RHP José Soriano (10-10, 4.07) in the opener of a four-game series Thursday night.