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The Nooksack River is expected to crest at just over 23 ft., which puts it slightly over major flood stage levels.
County officials are urging drivers not to drive past road closed signs.
The Nooksack River at North Cedarville crested early Thursday morning and is expected to fall back to action stage later in the night.
The NWS has issued a flash flood watch for the Skagit River Basin due to potential levee and dam failures.
The Division Street Bridge to and from West Mount Vernon is closing at 6 pm on Thursday.
The Nooksack River at Ferndale is expected to see the most flooding when it crests around 21 ft. on Thursday afternoon, which puts it just above the moderate flood stage.
Anyone in the impacted flood areas should secure their belongings and property, get a go bag ready and have an evacuation route planned.
Communities often impacted include Marblemount, Rockport, Concrete, Hamilton, Lyman and surrounding areas.
The National Weather Service has issued a flood warning for Skagit County until further notice.
Whatcom County has closed multiple roads due to weather/flood conditions.