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The Cardinals trailed 20-6 midway through the fourth.
The streaking Mariners clinched the fourth division crown in the franchise’s 49-year history.
Rockies RHP Tanner Gordon (6-7, 6.00 ERA) starts Wednesday against Mariners RHP Luis Castillo (10-8, 3.63).
The Astros never led in the series and went 2 for 20 with runners in scoring position.
The Seahawks visit Arizona on Thursday.
The Mariners begin their pivotal series in Houston with RHP Bryan Woo (14-7, 3.02 ERA) on the mound Friday night.
The teams complete their three-game series on Thursday.
The Storm will play at Las Vegas on Thursday for a spot in the WNBA semifinals.
Mariners RHP Bryce Miller (4-5, 5.59 ERA) gets the start Wednesday night after striking out a career-high 11 in his last start against the Angels.
Mariners: RHP Logan Gilbert (4-6, 3.54) starts Tuesday at Kansas City, which goes with RHP Michael Wacha (9-11, 3.45).