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WSDOT announced the closure following 15 inches of snowfall surrounding the highway, posing an avalanche risk in the area.
The North Cascades Highway will be shut down through the weekend between the Ross Dam Trailhead and the Silver Star Gate.
A draft report revealed that residents found the new bike lanes dangerous and unnecessary.
The closures are part of the roundabout upgrade project at the southbound I-5 ramps.
The installation project allowed the city to test out a more environmentally friendly product on a small section of sidewalk.
There is no estimated time for reopening.
The Small Area Paving Project is an annual effort to repair areas experiencing large or complex pavement failure.
The Slater Road off and on-ramps will be closed intermittently Oct. 28 through 31.
All lanes on I-5 northbound at Iowa Street (MP 254) are closed due to an apparent landslide on Sunday morning.
Crew will also begin working on a multi-year sewer project in the same area.