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Drivers should expect one-lane closures with flaggers guiding traffic during construction.
Crews will be clearing catch basins and ditches, removing hazardous trees and making guardrail and shoulder repairs as part of early winter maintenance.
The semi flipped on its side just after 9 a.m. Wednesday morning.
Samish Park was also closed as part of the bridge work, and will remain closed until further notice.
The Mt. Baker Hill Climb starts at Snowater Road near Chair 9 and takes cyclists on a 22.4-mile ride along the Nooksack River before climbing up to Artist Point on Mount Baker with a total elevation gain of 4,482 ft.
WSDOT says that construction will begin on Tuesday night for the southbound lanes in Ferndale.
Congestion is expected to be at its heaviest between 11 a.m. and 5 p.m. Saturday and Sunday.
Repairs made to the bridge will fix the failing paint system, corrosion and pack rust to metal elements, missing fasteners and leaking joints among other things.
Drivers are advised to plan for delays using alternative routes.
Drivers should expect delays in Seattle this weekend and overnight in north Bellingham starting Sunday night.