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Edwin Díaz pitched the ninth for his fifth save after coming off the injured list earlier in the day.
Emerson Hancock is on the mound tonight in what could be his final start as a Mariner.
Natisha Hiedeman sank six 3-pointers and scored a career-high 33 for Seattle.
Mariners starter Luis Castillo allowed five runs and 11 hits in five innings.
All four homers came in the first three innings off George Kirby (8-9).
Andrew Thomas had five saves for Seattle.
Andrés Muñoz struck out the side in the ninth for his 18th save in 23 chances.
Fans can catch the Seahawks training camp through Aug. 13 in Renton, while the first episode of Hard Knocks comes out on Aug. 4.
The Mariners are about to begin a critical series against the Rangers for the AL West lead.
Cal Raleigh, last year’s AL MVP runner-up, drove in six runs during the series, including a grand slam on Monday.