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Seahawks wide receiver Jake Bobo was carted off the field Friday from Seattle’s joint practice with the Titans and was placed on injured reserve Saturday.
Seattle (62-69) remained three games behind Houston in the AL West.
The Seahawks could be without a fan-favorite receiver for the entire season.
The Mariners are reportedly calling up the top pitching prospect in baseball to start in Seattle on Saturday.
Seattle improved to 4-4 in a nine-game trip that concludes Thursday.
The Seahawks have reportedly agreed to a one-year deal with former Cowboys Pro Bowler Trevon Diggs.
The only other 22-0 victories since 1901 were by Pittsburgh over the host Chicago Cubs on Sept. 16, 1975 and by Cleveland at the New York Yankees on Aug. 31, 2004.
Bryce Miller and the Mariners are opening a series against the best team in baseball tonight.
The Mariners now sit four games behind the Astros after taking two out of three in Houston over the weekend.
Seattle forward Jesús Ferreira left with a leg injury in the 36th minute.